The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
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The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
The receptor-like protein tyrosine phosphatase CD45 is expressed on the surface of cells of hematopoietic origin and has a pivotal role for the function of these cells in the immune response. Here we report that following infection of macrophages with mouse cytomegalovirus (MCMV) the cell surface expression of CD45 is drastically diminished. Screening of a set of MCMV deletion mutants allowed u...
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متن کاملCD45-associated protein inhibits CD45 dimerization and upregulates its protein tyrosine phosphatase activity Running head: CD45-AP INHIBITS CD45 DIMERIZATION
CD45, a receptor-like protein tyrosine phosphatase (PTP), plays an essential role in lymphocyte development and immune responses. Recent evidence suggests that dimerization of CD45 downregulates its function. However, the mechanisms by which CD45 dimerization is regulated remain unclear and there is no direct evidence that the PTP activity of CD45 dimers is less than that of monomers. CD45 in l...
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15 صفحه اولIMMUNOBIOLOGY CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity
CD45, a receptor-like protein tyrosine phosphatase (PTP), plays an essential role in lymphocyte development and immune responses. Recent evidence suggests that dimerization of CD45 downregulates its function. However, the mechanisms by which CD45 dimerization is regulated remain unclear, and there is no direct evidence that the PTP activity of CD45 dimers is less than that of monomers. CD45 in ...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2016
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1006057